Randomized clinical trials in rectal and anal cancer Journal Article

  


Authors: Nissan, A.; D'Angelica, M. I.; Shoup, M. C.; Hartley, J. E.; Jaques, D. P.
Article Title: Randomized clinical trials in rectal and anal cancer
Abstract: Treatment of rectal cancer has changed dramatically over the past two decades. Radical surgery alone for resectable rectal cancer has been replaced by combined modality therapy. Interest in optimizing sphincter preservation and quality of life motivated surgeons to seek less radical surgery without compromising oncologic principles. The treatment of advanced colorectal cancer has long been a dilemma for clinicians. After many years of therapy limited to 5-fluorouracil (5-FU)-based chemotherapy, a number of new discoveries have significantly advanced this field in the last decade. The advent of irinotecan has given us hope for a second line chemotherapeutic agent and a possible new combination for first line chemotherapy.
Keywords: cancer chemotherapy; controlled study; clinical trial; review; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; fluorouracil; cancer radiotherapy; prospective studies; evidence-based medicine; quality of life; controlled clinical trial; randomized controlled trial; vincristine; randomized controlled trials; folinic acid; medical oncology; mitomycin c; preoperative treatment; anus cancer; rectal neoplasms; rectum cancer; preservation; rectum abdominoperineal resection; anus neoplasms; semustine; humans; human
Journal Title: Surgical Oncology Clinics of North America
Volume: 11
Issue: 1
ISSN: 1055-3207
Publisher: Elsevier Inc.  
Date Published: 2002-01-01
Start Page: 149
End Page: 172
Language: English
DOI: 10.1016/s1055-3207(03)00079-6
PUBMED: 11928798
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0036136585&partnerID=40&md5=aa5b32c0787d839acbf7065f5fad4b2b
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. John E Hartley
    4 Hartley
  2. Margaret Shoup
    20 Shoup
  3. Aviram Nissan
    20 Nissan
  4. David P Jaques
    66 Jaques
  5. Michael D'Angelica
    777 D'Angelica
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