Adjuvant external beam and intraoperative radiation therapy in rectal cancer Journal Article

  


Authors: Minsky, B. D.; Cohen, A. M.
Article Title: Adjuvant external beam and intraoperative radiation therapy in rectal cancer
Abstract: The use of radical surgery has maximized local control, sphincter preservation, and overall survival in patients with rectal cancer. Despite the advances in surgical techniques, local recurrence still remains a problem. Following potentially curative surgery, the incidence of local recurrence inpatients with stages B2,C disease varies from 15% to 65% There are four major approaches in which radiation therapy (RT) has been used in the adjuvant treatment of rectal cancer. These include postoperative RT ± chemotherapy, preoperative RT ± chemotherapy, both pre-and postoperative RT (sandwich technique), and intraoperative RT in conjunction with preoperative external beam RT. In patients with resectable rectal cancer, adjuvant RT has been shown to decrease the incidence of local recurrence and, in some series, may influence survival rates. In patients with locally advanced, unresectable, or recurrent rectal cancer, the use of preoperative radiation therapy, attempted surgical resection, and intraoperative RT further enhances local control. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: review; cancer radiotherapy; postoperative care; preoperative care; combined modality therapy; intraoperative care; neoplasm recurrence, local; radiation; radiotherapy; rectal neoplasms; rectum cancer; random allocation; human
Journal Title: Cancer Investigation
Volume: 7
Issue: 5
ISSN: 0735-7907
Publisher: Informa Healthcare  
Date Published: 1989-01-01
Start Page: 493
End Page: 507
Language: English
DOI: 10.3109/07357908909041379
PUBMED: 2695231
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024957572&doi=10.3109%2f07357908909041379&partnerID=40&md5=b8ba2122762342f79a664fb976b4506f
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Bruce Minsky
    306 Minsky
  2. Alfred M Cohen
    244 Cohen
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