Autophagy in cellular metabolism and cancer Journal Article
| Authors: | Jiang, X.; Overholtzer, M.; Thompson, C. B. |
| Article Title: | Autophagy in cellular metabolism and cancer |
| Abstract: | Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient signaling through the ULK1 autophagy pre-initiation complex. Furthermore, related cellular processes utilizing components of the canonical autophagy pathway are discussed due to their potential roles in nutrient scavenging. Finally, the role of autophagy in cancer and its potential as a cancer therapeutic target are considered. |
| Keywords: | protein expression; protein phosphorylation; unclassified drug; gene deletion; review; nonhuman; antineoplastic agent; neoplasm; cell death; cell survival; apoptosis; ubiquitin protein ligase; protein degradation; cell protein; protein; phosphatidylinositol 3 kinase; cancer therapy; carcinogenesis; lung tumor; cancer inhibition; cancer cell; pancreas tumor; mammalian target of rapamycin; pancreas adenocarcinoma; ras protein; tumor growth; autophagy; liver adenoma; cell activation; cell metabolism; protein kinase; phagosome; multiple cancer; b raf kinase; cell activity; oncogene ras; protein p62; conjugation; cell vacuole; citric acid cycle; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); biodegradation; protein acetylation; autophagosome; beclin 1; transcription factor nrf2; pinocytosis; kelch like ech associated protein 1; metabolic stress; human; autophagy related gene protein; unc 51 like autophagy activating kinase 1 protein kinase |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 125 |
| Issue: | 1 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2015-01-02 |
| Start Page: | 47 |
| End Page: | 54 |
| Language: | English |
| DOI: | 10.1172/jci73942 |
| PROVIDER: | scopus |
| PMCID: | PMC4382242 |
| PUBMED: | 25654550 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
81Overholtzer -
121Jiang -
153Thompson
Related MSK Work