Interplay between autophagy and apoptosis in cancer: Mechanisms and therapeutic implications Journal Article
| Author: | Sharma, M. |
| Article Title: | Interplay between autophagy and apoptosis in cancer: Mechanisms and therapeutic implications |
| Abstract: | Autophagy and apoptosis play pivotal roles in maintaining cellular homeostasis through complex molecular mechanisms, and their dysregulation can impact cancer progression. The interplay between autophagy, a conserved catabolic process and apoptosis, a regulated form of cell death under physiological conditions, is the burgeoning area of cancer research. In response to cellular stress, autophagy eliminates misfolded/unfolded proteins and dysfunctional organelles, while apoptosis damaged or potentially harmful cells, contributing to tumor suppression. However, in certain cases depending on cellular context and tumor stage, autophagy aids tumor survival by helping cells to overcome extremely stressful conditions like nutrient starvation and hypoxia potentially leading to treatment resistance. The crosstalk between autophagy and apoptosis is mediated by some common regulators, and an imbalance in either of their levels can establish the progression of tumor. The paradoxical role of autophagy as an executioner of cell death and a tumor protector is still controversial. Therefore, comprehending the molecular mechanisms that underlie the connections between autophagy and apoptosis is crucial for deriving valuable insights that can inform the development of effective therapeutic strategies in the treatment of cancer. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. |
| Keywords: | signal transduction; mitogen activated protein kinase; vasculotropin; cancer survival; somatic mutation; cancer growth; solid tumor; gemcitabine; cancer patient; pancreas cancer; temozolomide; cancer staging; prostate specific antigen; dna damage; cell survival; ipilimumab; protein bcl 2; cancer immunotherapy; melanoma; apoptosis; multiple myeloma; ovary cancer; breast cancer; stress activated protein kinase; fas ligand; caspase 3; cytotoxicity; protein p53; cancer inhibition; b cell lymphoma; immune response; genomic instability; immunogenicity; protein mcl 1; mammalian target of rapamycin; reactive oxygen metabolite; ras protein; hydroxychloroquine; caspase 8; caspase 9; oxidative stress; tumor growth; autophagy; homeostasis; chronic lymphatic leukemia; mitochondrion; glycolysis; lysosome; tumor necrosis factor; metabolic regulation; non-hodgkin lymphoma; chloroquine; tumor microenvironment; phase 2 clinical trial (topic); cancer growth factor; phase 3 clinical trial (topic); phase 1 clinical trial (topic); pancreas metastasis; huntington chorea; crosstalk; autophagosome; beclin 1; epstein barr virus infection; transcription factor nrf2; apoptotic protease activating factor 1; x linked inhibitor of apoptosis; endoplasmic reticulum stress; cellular stress; tumor immunogenicity; immune checkpoint inhibitor; mitophagy; nivolumab; physiological stress; ramucirumab; tumor necrosis factor receptor associated factor 2; cancer; human; pembrolizumab; endonuclease g; apoptosis rate; malignant neoplasm; autophagy (cellular); baculoviral iap repeat containing protein 5; checkpoint inhibitor therapy; death domain receptor signaling adaptor protein; paricalcitol; epstein-barr virus-associated gastric carcinoma |
| Journal Title: | Cancer Drug Discovery and Development |
| ISSN: | 2196-9906 |
| Publisher: | Humana Press Inc |
| Date Published: | 2024-01-01 |
| Start Page: | 235 |
| End Page: | 254 |
| Language: | English |
| DOI: | 10.1007/978-3-031-66421-2_11 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 11 in "Role of Autophagy and Reactive Oxygen Species in Cancer Treatment" (ISBN: 978-3-031-66420-5) -- Source: Scopus |
