Application of hitherto unexplored macrocyclization strategies in the epothilone series: Novel epothilone analogs by total synthesis Journal Article

  


Authors: Njardarson, J. T.; Biswas, K.; Danishefsky, S. J.
Article Title: Application of hitherto unexplored macrocyclization strategies in the epothilone series: Novel epothilone analogs by total synthesis
Abstract: A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki-Kishi macrocyclization is described.
Keywords: chemical structure; cyclization; boronic acid derivative; vinyl derivative; synthesis; epothilone derivative; alkene derivative; article; aldehyde derivative
Journal Title: Chemical Communications
Issue: 23
ISSN: 1359-7345
Publisher: Royal Society of Chemistry  
Date Published: 2002-01-01
Start Page: 2759
End Page: 2761
Language: English
PROVIDER: scopus
PUBMED: 12478733
DOI: 10.1039/B209941A
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0036436316&partnerID=40&md5=23bacf1970b82f2e2d1dfd88a9936531
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Kaustav Biswas
    10 Biswas
  2. Jon Njardarson
    9 Njardarson
  3. Samuel J Danishefsky
    539 Danishefsky
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