Peptoid macrocycles: Making the rounds with peptidomimetic oligomers Journal Article
| Authors: | Yoo, B.; Shin, S. B. Y.; Huang, M. L.; Kirshenbaum, K. |
| Article Title: | Peptoid macrocycles: Making the rounds with peptidomimetic oligomers |
| Abstract: | Macrocyclic constraints are often employed to rigidify the conformation of flexible oligomeric systems. This approach has recently been used to organize the structure of peptoid oligomers, which are peptidomimetics composed of chemically diverse N-substituted glycine monomer units. In this review, we describe advances in the synthesis and characterization of cyclic peptoids. We evaluate how the installation of covalent constraints between the oligomer termini or side chains has been effective in defining peptoid conformations. We also discuss the potential applications for this promising family of macrocyclic peptidomimetics. © 2010 Wiley-VCH Verlag GmbH& Co. KGaA. |
| Keywords: | synthesis (chemical); side chains; macrocycles; conformations; foldamers; peptidomimetics; peptoids; macrocyclic peptidomimetics; macrocyclics; monomer units; potential applications; synthesis and characterization; amphiphiles; oligomers |
| Journal Title: | Chemistry - A European Journal |
| Volume: | 16 |
| Issue: | 19 |
| ISSN: | 0947-6539 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2010-05-17 |
| Start Page: | 5527 |
| Language: | English |
| DOI: | 10.1002/chem.200903549 |
| PROVIDER: | scopus |
| PUBMED: | 20414912 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CEUJE" - "Source: Scopus" |
