Effects of temperature and concentration in some ring closing metathesis reactions Journal Article
| Authors: | Yamamoto, K.; Biswas, K.; Gaul, C.; Danishefsky, S. J. |
| Article Title: | Effects of temperature and concentration in some ring closing metathesis reactions |
| Abstract: | Ring closing metathesis (RCM) has emerged as a powerful tool to construct macrocyclic ring systems. However, the product distribution of monomer and oligomers is often a problem in the formation of medium to large rings. In the course of synthetic studies on the natural product radicicol and its analogs, we have found that the reaction temperature, along with concentration, has significant impact on the outcome of the product ratio. Specifically, carrying out the RCM reaction in refluxing toluene (110°C) at higher dilution affords improved yields of the monomeric macrocycle. Similar observations for another family of macrolactone natural products, the epothilones, are also reported. © 2003 Elsevier Science Ltd. All rights reserved. |
| Keywords: | natural product; concentration (parameters); nuclear magnetic resonance; temperature sensitivity; chemical reaction; ring closing metathesis; monomer; epothilone derivative; epothilone; observation; radicicol; lactone derivative; oligomer; dilution; toluene; article; product distribution; rcm |
| Journal Title: | Tetrahedron Letters |
| Volume: | 44 |
| Issue: | 16 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2003-04-14 |
| Start Page: | 3297 |
| End Page: | 3299 |
| Language: | English |
| DOI: | 10.1016/s0040-4039(03)00618-x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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539Danishefsky
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