Total synthesis of (-)-epothilone B: An extension of the Suzuki coupling method and insights into structure-activity relationships of the epothilones Journal Article

  


Authors: Su, D. S.; Meng, D.; Bertinato, P.; Balog, A.; Sorensen, E. J.; Danishefsky, S. J.; Zheng, Y. H.; Chou, T. C.; He, L.; Horwitz, S. B.
Article Title: Total synthesis of (-)-epothilone B: An extension of the Suzuki coupling method and insights into structure-activity relationships of the epothilones
Abstract: The highest biological activities displayed by epothilone-related compounds have been found for epothilone B (1) and a derivative that was prepared en route to the natural product. Key steps in the total synthesis were a Suzuki coupling providing a trisubstituted double bond in the macrocycle and its subsequent stereoselective epoxidation with dimethyldioxirane.
Keywords: total synthesis; antitumor agents; epothilone; natural products
Journal Title: Angewandte Chemie - International Edition
Volume: 36
Issue: 7
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 1997-04-18
Start Page: 757
End Page: 759
Language: English
PROVIDER: scopus
DOI: 10.1002/anie.199707571
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030792331&partnerID=40&md5=543cae685810603386ae0e2b4fc39753
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Aaron Balog
    14 Balog
  2. Samuel J Danishefsky
    539 Danishefsky
  3. Ting-Chao Chou
    319 Chou
  4. Dongfang Meng
    17 Meng
  5. Dai-Shi Su
    12 Su
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