Total synthesis of (-)-epothilone A Journal Article
| Authors: | Balog, A.; Meng, D.; Kamenecka, T.; Bertinato, P.; Su, D. S.; Sorensen, E. J.; Danishefsky, S. J. |
| Article Title: | Total synthesis of (-)-epothilone A |
| Abstract: | An audacious macroaldolization is the key step in the first total synthesis of the cytotoxic epothilone A, which starts with the units 1, 2, and 3. This condensation closes the ring to form the macrolide, whose structure was determine and published (also in Angewandte Chemie) as recently as July 1996. |
| Keywords: | cyclization; epothilone; natural products; c-c coupling; synthesis methods |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 35 |
| Issue: | 23-24 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1996-12-01 |
| Start Page: | 2801 |
| End Page: | 2803 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1002/anie.199628011 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
