Application of ring-closing metathesis reactions in the synthesis of epothilones Journal Article
| Authors: | Rivkin, A.; Cho, Y. S.; Gabarda, A. E.; Yoshimura, F.; Danishefsky, S. J. |
| Article Title: | Application of ring-closing metathesis reactions in the synthesis of epothilones |
| Abstract: | There is wide interest in the epothilones, which like the taxoids initiate cytotoxicity through microtubule stabilization. Briefly described is an application of a ring-closing metathesis reaction toward the synthesis of epothilones as carried out in our laboratory. This has led to the discovery of the (E)-9,10-dehydroepothilones as second-generation anticancer drug candidates. |
| Keywords: | paclitaxel; family; taxol; drug discovery process |
| Journal Title: | Journal of Natural Products |
| Volume: | 67 |
| Issue: | 2 |
| ISSN: | 0163-3864 |
| Publisher: | American Chemical Society |
| Date Published: | 2004-01-24 |
| Start Page: | 139 |
| End Page: | 143 |
| Language: | English |
| ACCESSION: | WOS:000220023300004 |
| DOI: | 10.1021/np030540k |
| PROVIDER: | wos |
| PUBMED: | 14987048 |
| Notes: | Review -- Source: Wos |
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