Randomized, placebo-controlled trial of dietary supplementation of α-tocopherol on mutagen sensitivity levels in melanoma patients: A pilot trial Journal Article
| Authors: | Mahabir, S.; Coit, D.; Liebes, L.; Brady, M. S.; Lewis, J. J.; Roush, G.; Nestle, M.; Fry, D.; Berwick, M. |
| Article Title: | Randomized, placebo-controlled trial of dietary supplementation of α-tocopherol on mutagen sensitivity levels in melanoma patients: A pilot trial |
| Abstract: | We evaluated the effects of vitamin E (DL-α-tocopherol) on mutagen sensitivity levels in a randomized placebo-controlled pilot trial. In brief, a dietary supplement of 1000 mg/day vitamin E or a placebo was randomly administered for 3 months to melanoma outpatients clinically free of the disease. Plasma vitamin E and mutagen sensitivity levels were measured at baseline and at the end of the trial after 3 months. At baseline, we found no significant differences in plasma vitamin E and mutagen sensitivity levels between the two groups. We also measured dietary intake at baseline and found dietary vitamin E to be a poor predictor of plasma levels of vitamin E. After 3 months of supplementation, we found that plasma levels of α-tocopherol increased significantly (P= 0.0005) in the vitamin E compared to the placebo group. We also found a non-significant, but consistent decrease in plasma γ-tocopherol concentrations in the vitamin E supplemented compared to the placebo group. We did not find any significant difference between the vitamin E and placebo groups in mutagen sensitivity levels either at baseline or after 3 months of supplementation. We conclude that short term vitamin E supplementation, although it causes increased blood levels of α-tocopherol, does not provide protection against bleomycin-induced chromosome damage. © 2002 Lippincott Williams & Wilkins. |
| Keywords: | adult; clinical article; controlled study; aged; middle aged; clinical trial; cells, cultured; cancer prevention; melanoma; controlled clinical trial; randomized controlled trial; diet supplementation; pilot projects; bleomycin; outpatient; dietary supplements; alpha tocopherol; drug blood level; dietary intake; antibiotics, antineoplastic; double blind procedure; lymphocytes; drug sensitivity; chromosomes; placebos; genotoxicity; mutagens; vitamin e; chromosome damage; alpha-tocopherol; mutagen testing; humans; human; male; female; priority journal; article; gamma-tocopherol; mutagen sensitivity |
| Journal Title: | Melanoma Research |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 0960-8931 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2002-02-01 |
| Start Page: | 83 |
| End Page: | 90 |
| Language: | English |
| DOI: | 10.1097/00008390-200202000-00012 |
| PUBMED: | 11828262 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work