Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis Journal Article
| Authors: | DeCosse, J. J.; Miller, H. H.; Lesser, M. L. |
| Article Title: | Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis |
| Abstract: | Over a 4-year period in a chemoprevention trial on large bowel neoplasia, 58 patients with familial adenomatous polyposis were treated with 4 g of ascorbic acid (vitamin C)/day plus 400 mg of α-tocopherol (vitamin E)/day alone or with a grain fiber supplement (22.5 g/day). In this randomized, double-blind, placebo-controlled study, we determined the effects of these supplements on rectal polyps in these patients. Analysis by intent to treat suggested that the high-fiber supplement had a limited effect. Analysis adjusted for patient compliance showed a stronger benefit from the high-fiber supplement during the middle 2 years of the trial. The results provide evidence for inhibition of benign large bowel neoplasia by grain fiber supplements in excess of 11 g/day in this study population. The findings are consistent with the hypothesis that dietary grain fiber and total dietary fat act as competing variables in the genesis of large bowel neoplasia. [J Natl Cancer Inst 81:1290-1297, 1989]. © 1989 Oxford University Press. |
| Keywords: | adult; controlled study; major clinical study; colorectal cancer; diet; patient compliance; alpha tocopherol; ascorbic acid; double-blind method; clinical trials; polyps; placebos; adenomatous polyp; random allocation; vitamin e; adenomatous polyposis coli; rectum polyp; rectal diseases; colon polyposis; dietary fiber; human; priority journal; wheat bran; support, u.s. gov't, p.h.s.; triticum |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 81 |
| Issue: | 17 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 1989-09-06 |
| Start Page: | 1290 |
| End Page: | 1297 |
| Language: | English |
| DOI: | 10.1093/jnci/81.17.1290 |
| PUBMED: | 2549261 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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