Analysis of patients with epithelial ovarian cancer or fallopian tube carcinoma retreated with cisplatin after the development of a carboplatin allergy Journal Article

  

Authors:	Dizon, D. S.; Sabbatini, P. J.; Aghajanian, C.; Hensley, M. L.; Spriggs, D. R.
Article Title:	Analysis of patients with epithelial ovarian cancer or fallopian tube carcinoma retreated with cisplatin after the development of a carboplatin allergy
Abstract:	Objective. We report the outcome of seven patients treated for recurrent ovarian cancer with cisplatin after an allergic reaction to carboplatin. One case is presented in which a heavily pretreated patient suffered a severe anaphylactic reaction, which was refractory to standard resuscitative measures and resulted in her death. Methods. Six further patients who received cisplatin after documentation of an allergic reaction to carboplatin (CBDCA) for the treatment of recurrent epithelial ovarian cancer between 1993 and 2000 were identified from the MSKCC database. Electronic medical records were reviewed for relevant treatment and outcome data. Results. Five of six of these patients were successfully treated without further allergic reactions. One patient with platinum-refractory disease had an allergic reaction to carboplatin and subsequently to cisplatin. Conclusion. Few patients with a carboplatin allergy are subsequently treated with cisplatin at our center. One patient suffered a serious hypersensitivity reaction following retreatment and died. Based on this limited experience, cross allergy can exist although the true incidence is not known. Routine retreatment of carboplatin-allergic patients with cisplatin in the relapsed setting cannot be recommended without careful consideration of potential risks and benefits. © 2002 Elsevier Science (USA).
Keywords:	adult; controlled study; treatment outcome; aged; middle aged; major clinical study; clinical feature; disease course; cisplatin; drug withdrawal; antineoplastic agents; paclitaxel; recurrent cancer; ovarian neoplasms; carboplatin; cyclophosphamide; dexamethasone; drug hypersensitivity; rash; hypoxia; ovary carcinoma; nausea and vomiting; uterine tube carcinoma; fallopian tube neoplasms; fatal outcome; oxygen saturation; diphenhydramine; cimetidine; vertigo; humans; human; female; priority journal; article
Journal Title:	Gynecologic Oncology
Volume:	84
Issue:	3
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2002-03-01
Start Page:	378
End Page:	382
Language:	English
DOI:	10.1006/gyno.2001.6519
PUBMED:	11855873
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200063&partnerID=40&md5=0588e286d35cf6aba9e253d3422730fe
Notes:	Export Date: 14 November 2014 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/66497