Chemotherapy-induced neutropenia and fever in patients receiving cisplatin-based chemotherapy for ovarian malignancy Journal Article
| Authors: | Curtin, J. P.; Hoskins, W. J.; Rubin, S. C.; Jones, W. B.; Hakes, T. B.; Markman, M. M.; Reichman, B.; Almadrones, L.; Lewis, J. L. Jr |
| Article Title: | Chemotherapy-induced neutropenia and fever in patients receiving cisplatin-based chemotherapy for ovarian malignancy |
| Abstract: | Fifty-six episodes of chemotherapy-induced neutropenia and fever occurred in forty-three patients receiving cisplatin-based combination chemotherapy for ovarian cancer. All patients were treated with broad-spectrum antibiotics including gentamicin. Twelve of fifty-six episodes were associated with positive cultures; in six patients a single organism was isolated, and the other six patients had polymicrobial infection. The mean duration of antibiotic therapy was 6.5 days. One patient died of sepsis. Fifty-five episodes had a successful outcome. There was no antibioti-crelated morbidity. Based on this review we recommend broad-spectrum antibiotic therapy for chemotherapy-induced neutropenia with fever. The regimen of gentamicin plus ticarcillin and clavulanic acid (ceftazidime for penicillin-allergic patients) is effective as initial therapy. Additional agents (i.e., vancomycin) may be necessary in culture-positive patients based on sensitivity testing of bacterial isolates. Gentamicin can be safely administered to patients receiving cisplatin-based chemotherapy without compromising ability to continue cisplatin therapy in subsequent treatment cycles. © 1991. |
| Keywords: | adult; aged; aged, 80 and over; retrospective studies; major clinical study; neutropenia; review; cisplatin; doxorubicin; fluorouracil; cytarabine; ovarian neoplasms; ovary cancer; etoposide; cyclophosphamide; vinblastine; fever; length of stay; dactinomycin; bleomycin; gentamicin; vancomycin; bacterial infections; middle age; ceftazidime; clavulanic acid; gentamicins; human; female; priority journal; ticarcillin; antibiotics, aminoglycoside; antibiotics, combined |
| Journal Title: | Gynecologic Oncology |
| Volume: | 40 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1991-01-01 |
| Start Page: | 17 |
| End Page: | 20 |
| Language: | English |
| DOI: | 10.1016/0090-8258(91)90077-i |
| PUBMED: | 1989909 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
