Long-term outcomes following microwave ablation for liver malignancies Journal Article

Authors: Leung, U.; Kuk, D.; D'Angelica, M. I.; Kingham, T. P.; Allen, P. J.; DeMatteo, R. P.; Jarnagin, W. R.; Fong, Y.
Article Title: Long-term outcomes following microwave ablation for liver malignancies
Abstract: Background Microwave ablation has emerged as a promising treatment for liver malignancies, but there are scant long-term follow-up data. This study evaluated long-term outcomes, with a comparison of 915-MHz and 2·4-GHz ablation systems. Justified in selected patients Methods This was a retrospective review of patients with malignant liver tumours undergoing operative microwave ablation with or without liver resection between 2008 and 2013. Regional or systemic (neo)adjuvant therapy was given selectively. Local recurrence was analysed using competing-risk methods with clustering, and overall survival was determined from Kaplan-Meier curves. Results A total of 176 patients with 416 tumours were analysed. Colorectal liver metastases (CRLM) comprised 81·0 per cent of tumours, hepatocellular carcinoma 8·4 per cent, primary biliary cancer 1·7 per cent and non-CRLM 8·9 per cent. Median follow-up was 20·5 months. Local recurrence developed after treatment of 33 tumours (7·9 per cent) in 31 patients (17·6 per cent). Recurrence rates increased with tumour size, and were 1·0, 9·3 and 33 per cent for lesions smaller than 1 cm, 1-3 cm and larger than 3 cm respectively. On univariable analysis, the local recurrence rate was higher after ablation of larger tumours (hazard ratio (HR) 2·05 per cm; P < 0·001), in those with a perivascular (HR 3·71; P = 0·001) or subcapsular (HR 2·71; P = 0·008) location, or biliary or non-CRLM histology (HR 2·47; P = 0·036), and with use of the 2·4-GHz ablation system (HR 3·79; P = 0·001). Tumour size (P < 0·001) and perivascular position (P = 0·045) remained significant independent predictors on multivariable analysis. Regional chemotherapy was associated with decreased local recurrence (HR 0·49; P = 0·049). Overall survival at 4 years was 58·3 per cent for CRLM and 79·4 per cent for other pathology (P = 0·360). Conclusion Microwave ablation of liver malignancies, either combined or not combined with liver resection, and selective regional and systemic therapy resulted in good long-term survival. Local recurrence rates were low after treatment of tumours smaller than 3 cm in diameter, and those remote from vessels. Promising new treatment © 2014 BJS Society Ltd. Published by John Wiley & Sons Ltd.
Journal Title: British Journal of Surgery
Volume: 102
Issue: 1
ISSN: 0007-1323
Publisher: John Wiley & Sons  
Date Published: 2015-01-01
Start Page: 85
End Page: 91
Language: English
DOI: 10.1002/bjs.9649
PROVIDER: scopus
PUBMED: 25296639
PMCID: PMC4593505
Notes: Export Date: 2 January 2015 -- Source: Scopus
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MSK Authors
  1. Ronald P DeMatteo
    613 DeMatteo
  2. Peter Allen
    459 Allen
  3. William R Jarnagin
    609 Jarnagin
  4. Yuman Fong
    749 Fong
  5. T Peter Kingham
    301 Kingham
  6. Deborah Kuk
    81 Kuk
  7. Universe Yu Hang Leung
    12 Leung