A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases Journal Article

Authors: Correa-Gallego, C.; Fong, Y.; Gonen, M.; D'Angelica, M. I.; Allen, P. J.; DeMatteo, R. P.; Jarnagin, W. R.; Kingham, T. P.
Article Title: A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases
Abstract: Background: Microwave (MWA) and radiofrequency ablation (RFA) are the most commonly used techniques for ablating colorectal-liver metastases (CRLM). The technical and oncologic differences between these modalities are unclear. Methods: We conducted a matched-cohort analysis of patients undergoing open MWA or RFA for CRLM at a tertiary-care center between 2008 and 2011; the primary endpoint was ablation-site recurrence. Tumors were matched by size, clinical-risk score, and arterial-intrahepatic or systemic chemotherapy use. Outcomes were compared using conditional logistic regression and stratified log-rank test. Results: We matched 254 tumors (127 per group) from 134 patients. MWA and RFA groups were comparable by age, gender, median number of tumors treated, proximity to major vessels, and postoperative complication rates. Patients in the MWA group had lower ablation-site recurrence rates (6% vs. 20%; P < 0.01). Median follow-up, however, was significantly shorter in the MWA group (18 months [95% confidence interval 17–20] vs. 31 months [95% confidence interval 28–35]; P < 0.001). Kaplan–Meier estimates of ablation-site recurrence at 2 years were significantly lower for the lesions treated with MWA (7% vs. 18%, P: 0.01). Conclusions: Ablation-site recurrences of CRLM were lower with MWA compared with RFA in this matched cohort analysis. Longer follow-up time in the MWA may increase the recurrence rate; however, actuarial local failure estimations demonstrated better local control with MWA.
Keywords: adult; cancer chemotherapy; cancer survival; controlled study; aged; cancer surgery; major clinical study; overall survival; cancer recurrence; follow up; antineoplastic agent; tumor volume; surgical infection; pleura effusion; radiofrequency ablation; microwave therapy; local recurrence free survival; colorectal liver metastasis; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 21
Issue: 13
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2014-12-01
Start Page: 4278
End Page: 4283
Language: English
DOI: 10.1245/s10434-014-3817-0
PROVIDER: scopus
PUBMED: 24889486
PMCID: PMC4529120
Notes: Export Date: 2 January 2015 -- Source: Scopus
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MSK Authors
  1. Ronald P DeMatteo
    616 DeMatteo
  2. Mithat Gonen
    736 Gonen
  3. Peter Allen
    462 Allen
  4. William R Jarnagin
    612 Jarnagin
  5. Yuman Fong
    751 Fong
  6. T Peter Kingham
    305 Kingham
  7. Juan Camilo Correa
    25 Correa