The effect of histopathological growth patterns of colorectal liver metastases on the survival benefit of adjuvant hepatic arterial infusion pump chemotherapy Journal Article

   

Authors:	Filipe, W. F.; Meyer, Y. M.; Buisman, F. E.; Coebergh van den Braak, R. R. J.; Galjart, B.; Höppener, D. J.; Jarnagin, W. R.; Kemeny, N. E.; Kingham, T. P.; Nierop, P. M. H.; van der Stok, E. P.; Grünhagen, D. J.; Vermeulen, P. B.; Groot Koerkamp, B.; Verhoef, C.; D’Angelica, M. I.
Article Title:	The effect of histopathological growth patterns of colorectal liver metastases on the survival benefit of adjuvant hepatic arterial infusion pump chemotherapy
Abstract:	Background: Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM. Methods: Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively. Results: We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40). Conclusions: There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM. © 2023, The Author(s).
Keywords:	adult; cancer chemotherapy; cancer survival; controlled study; middle aged; cancer surgery; survival rate; retrospective studies; major clinical study; overall survival; histopathology; fluorouracil; cancer combination chemotherapy; cancer growth; systemic therapy; liver neoplasms; cancer adjuvant therapy; cancer patient; chemotherapy, adjuvant; outcome assessment; antineoplastic agent; progression free survival; multiple cycle treatment; cohort analysis; pathology; retrospective study; irinotecan; colorectal neoplasms; colorectal tumor; folinic acid; adjuvant chemotherapy; liver tumor; hepatectomy; oxaliplatin; floxuridine; predictive value; perioperative care; infusion pumps, implantable; metastasis resection; colorectal liver metastasis; humans; human; male; female; article; hepatic arterial infusion pump chemotherapy
Journal Title:	Annals of Surgical Oncology
Volume:	30
Issue:	13
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2023-12-01
Start Page:	7996
End Page:	8005
Language:	English
DOI:	10.1245/s10434-023-14342-1
PUBMED:	37782413
PROVIDER:	scopus
PMCID:	PMC10625931
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85173968244&doi=10.1245%2fs10434-023-14342-1&partnerID=40&md5=206a6381f7f8d784bfc4845cce20f373
Notes:	Article -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/211530