Histopathological growth patterns and positive margins after resection of colorectal liver metastases Journal Article

   


Authors: Nierop, P. M. H.; Höppener, D. J.; van der Stok, E. P.; Galjart, B.; Buisman, F. E.; Balachandran, V. P.; Jarnagin, W. R.; Kingham, T. P.; Allen, P. J.; Shia, J.; Vermeulen, P. B.; Groot Koerkamp, B.; Grünhagen, D. J.; Verhoef, C.; D'Angelica, M. I.
Article Title: Histopathological growth patterns and positive margins after resection of colorectal liver metastases
Abstract: Background: Histopathological growth patterns (HGPs) of colorectal liver metastases (CRLM) may be an expression of biological tumour behaviour impacting the risk of positive resection margins. The current study aimed to investigate whether the non-desmoplastic growth pattern (non-dHGP) is associated with a higher risk of positive resection margins after resection of CRLM. Methods: All patients treated surgically for CRLM between January 2000 and March 2015 at the Erasmus MC Cancer Institute and between January 2000 and December 2012 at the Memorial Sloan Kettering Cancer Center were considered for inclusion. Results: Of all patients (n = 1302) included for analysis, 13% (n = 170) had positive resection margins. Factors independently associated with positive resection margins were the non-dHGP (odds ratio (OR): 1.79, 95% confidence interval (CI): 1.11–2.87, p = 0.016) and a greater number of CRLM (OR: 1.15, 95% CI: 1.08–1.23 p < 0.001). Both positive resection margins (HR: 1.41, 95% CI: 1.13–1.76, p = 0.002) and non-dHGP (HR: 1.57, 95% CI: 1.26–1.95, p < 0.001) were independently associated with worse overall survival. Conclusion: Patients with non-dHGP are at higher risk of positive resection margins. Despite this association, both positive resection margins and non-dHGP are independent prognostic indicators of worse overall survival. © 2019 International Hepato-Pancreato-Biliary Association Inc.
Journal Title: HPB
Volume: 22
Issue: 6
ISSN: 1365-182X
Publisher: Elsevier Science, Inc.  
Date Published: 2020-06-01
Start Page: 911
End Page: 919
Language: English
DOI: 10.1016/j.hpb.2019.10.015
PUBMED: 31735649
PROVIDER: scopus
PMCID: PMC7888172
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075456632&doi=10.1016%2fj.hpb.2019.10.015&partnerID=40&md5=cec537e7f1721dd24822fefe8e5ca4e4
Notes: Article -- Export Date: 3 August 2020 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Jinru Shia
    720 Shia
  2. Peter Allen
    501 Allen
  3. William R Jarnagin
    907 Jarnagin
  4. Michael D'Angelica
    781 D'Angelica
  5. T Peter Kingham
    618 Kingham
  6. Vinod P Balachandran
    254 Balachandran
Related MSK Work