Self-organization of meiotic recombination initiation: General principles and molecular pathways Journal Article

   


Authors: Keeney, S.; Lange, J.; Mohibullah, N.
Article Title: Self-organization of meiotic recombination initiation: General principles and molecular pathways
Abstract: Recombination in meiosis is a fascinating case study for the coordination of chromosomal duplication, repair, and segregation with each other and with progression through a cell-division cycle. Meiotic recombination initiates with formation of developmentally programmed DNA double-strand breaks (DSBs) at many places across the genome. DSBs are important for successful meiosis but are also dangerous lesions that can mutate or kill, so cells ensure that DSBs are made only at the right times, places, and amounts. This review examines the complex web of pathways that accomplish this control. We explore how chromosome breakage is integrated with meiotic progression and how feedback mechanisms spatially pattern DSB formation and make it homeostatic, robust, and error correcting. Common regulatory themes recur in different organisms or in different contexts in the same organism. We review this evolutionary and mechanistic conservation but also highlight where control modules have diverged. The framework that emerges helps explain how meiotic chromosomes behave as a self-organizing system.
Keywords: nonhuman; dna replication; meiosis; cell cycle; molecular mechanics; saccharomyces cerevisiae; chromosome breakage; double stranded dna break; feedback system; caenorhabditis elegans; negative feedback; dna double-strand breaks; cell stress; prophase; atm; meiotic recombination; spo11; chromosome duplication; article
Journal Title: Annual Review of Genetics
Volume: 48
ISSN: 0066-4197
Publisher: Annual Reviews  
Date Published: 2014-11-01
Start Page: 187
End Page: 214
Language: English
DOI: 10.1146/annurev-genet-120213-092304
PROVIDER: scopus
PUBMED: 25421598
PMCID: PMC4291115
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84913555911&partnerID=40&md5=43c0d86bc5f9e7511c245a06ad5d0d94
Notes: Export Date: 2 January 2015 -- Source: Scopus
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MSK Authors
  1. Neeman Mohibullah
    15 Mohibullah
  2. Scott N Keeney
    138 Keeney
  3. Julian Lange
    18 Lange
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