Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation Journal Article


Authors: Keeney, S.; Neale, M. J.
Article Title: Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation
Abstract: Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases. ©2006 Biochemical Society.
Keywords: unclassified drug; review; nonhuman; meiosis; animals; dna damage; homologous recombination; enzyme degradation; protein protein interaction; protein binding; enzyme activity; dna; double stranded dna; enzyme phosphorylation; enzyme regulation; saccharomyces cerevisiae; recombination, genetic; immunoprecipitation; cell nucleus; yeast; catalysis; dna topoisomerase (atp hydrolysing); cyclin-dependent kinase; fungal protein; dna topoisomerase iv; chromosome segregation; spo11 protein; polyacrylamide gel electrophoresis; cyclin dependent kinase 1; arabidopsis; spo11; protein sae2; protein mer2; dna double-strand break; mre11-rad50-xrs2 complex; somatic crossing over
Journal Title: Biochemical Society Transactions
Volume: 34
Issue: 4
ISSN: 0300-5127
Publisher: Portland Press Ltd  
Date Published: 2006-08-01
Start Page: 523
End Page: 525
Language: English
DOI: 10.1042/bst0340523
PUBMED: 16856850
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 77" - "Export Date: 4 June 2012" - "CODEN: BCSTB" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Scott N Keeney
    103 Keeney
  2. Matthew John Neale
    5 Neale