Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation Journal Article
| Authors: | Keeney, S.; Neale, M. J. |
| Article Title: | Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation |
| Abstract: | Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases. ©2006 Biochemical Society. |
| Keywords: | unclassified drug; review; nonhuman; meiosis; animals; dna damage; homologous recombination; enzyme degradation; protein protein interaction; protein binding; enzyme activity; dna; double stranded dna; enzyme phosphorylation; enzyme regulation; saccharomyces cerevisiae; recombination, genetic; immunoprecipitation; cell nucleus; yeast; catalysis; dna topoisomerase (atp hydrolysing); cyclin-dependent kinase; fungal protein; dna topoisomerase iv; chromosome segregation; spo11 protein; polyacrylamide gel electrophoresis; cyclin dependent kinase 1; arabidopsis; spo11; protein sae2; protein mer2; dna double-strand break; mre11-rad50-xrs2 complex; somatic crossing over |
| Journal Title: | Biochemical Society Transactions |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 0300-5127 |
| Publisher: | Portland Press Ltd |
| Date Published: | 2006-08-01 |
| Start Page: | 523 |
| End Page: | 525 |
| Language: | English |
| DOI: | 10.1042/bst0340523 |
| PUBMED: | 16856850 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 77" - "Export Date: 4 June 2012" - "CODEN: BCSTB" - "Source: Scopus" |
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