Mechanisms of germ line genome instability Journal Article


Authors: Kim, S.; Peterson, S. E.; Jasin, M.; Keeney, S.
Article Title: Mechanisms of germ line genome instability
Abstract: During meiosis, numerous DNA double-strand breaks (DSBs) are formed as part of the normal developmental program. This seemingly destructive behavior is necessary for successful meiosis, since repair of the DSBs through homologous recombination (HR) helps to produce physical links between the homologous chromosomes essential for correct chromosome segregation later in meiosis. However, DSB formation at such a massive scale also introduces opportunities to generate gross chromosomal rearrangements. In this review, we explore ways in which meiotic DSBs can result in such genomic alterations. © 2016 Elsevier Ltd.
Keywords: meiosis; dna strand breakage; germ line; genomic instability; translocation; microhomology-mediated end joining (mmej); non-allelic homologous recombination (nahr); nonhomologous end joining (nhej); single-strand annealing (ssa)
Journal Title: Seminars in Cell and Developmental Biology
Volume: 54
ISSN: 1084-9521
Publisher: Elsevier Inc.  
Date Published: 2016-06-01
Start Page: 177
End Page: 187
Language: English
DOI: 10.1016/j.semcdb.2016.02.019
PROVIDER: scopus
PUBMED: 26880205
DOI/URL:
Notes: Review -- Export Date: 1 July 2016 -- Source: Scopus
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MSK Authors
  1. Scott N Keeney
    116 Keeney
  2. Maria Jasin
    230 Jasin
  3. Seo Young Kim
    4 Kim
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