The somatic genomic landscape of chromophobe renal cell carcinoma Journal Article
| Authors: | Davis, C. F.; Ricketts, C. J.; Wang, M.; Yang, L.; Cherniack, A. D.; Shen, H.; Buhay, C.; Kang, H.; Kim, S. C.; Fahey, C. C.; Hacker, K. E.; Bhanot, G.; Gordenin, D. A.; Chu, A.; Gunaratne, P. H.; Biehl, M.; Seth, S.; Kaipparettu, B. A.; Bristow, C. A.; Donehower, L. A.; Wallen, E. M.; Smith, A. B.; Tickoo, S. K.; Tamboli, P.; Reuter, V.; Schmidt, L. S.; Hsieh, J. J.; Choueiri, T. K.; Hakimi, A. A.; Cancer Genome Atlas Research, Network; Chin, L.; Meyerson, M.; Kucherlapati, R.; Park, W. Y.; Robertson, A. G.; Laird, P. W.; Henske, E. P.; Kwiatkowski, D. J.; Park, P. J.; Morgan, M.; Shuch, B.; Muzny, D.; Wheeler, D. A.; Linehan, W. M.; Gibbs, R. A.; Rathmell, W. K.; Creighton, C. J. |
| Article Title: | The somatic genomic landscape of chromophobe renal cell carcinoma |
| Abstract: | We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations. Copyright © 2014 Elsevier Inc. All rights reserved. |
| Keywords: | promoter region; genetics; molecular genetics; telomerase; dna methylation; kidney carcinoma; kidney neoplasms; molecular sequence data; kidney tumor; carcinoma, renal cell; promoter regions, genetic; human genome; nucleotide sequence; chromosome breakage; base sequence; dna mutational analysis; chromosome deletion; dna, mitochondrial; chromosomes, human; transcriptome; human chromosome; genome, human; mitochondrial dna; dna copy number variations; copy number variation; chromosome breakpoints; tert protein, human; exome; humans; human; article |
| Journal Title: | Cancer Cell |
| Volume: | 26 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2014-09-08 |
| Start Page: | 319 |
| End Page: | 330 |
| Language: | English |
| PUBMED: | 25155756 |
| PROVIDER: | scopus |
| PMCID: | PMC4160352 |
| DOI: | 10.1016/j.ccr.2014.07.014 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
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