Mitochondrial respiratory gene expression is suppressed in many cancers Journal Article

   

Authors:	Reznik, E.; Wang, Q.; La, K.; Schultz, N.; Sander, C.
Article Title:	Mitochondrial respiratory gene expression is suppressed in many cancers
Abstract:	The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expression of the nuclear genome (nuDNA). Previously we described mtDNA copy number depletion across many solid tumor types (Reznik et al., 2016). Here, we use orthogonal RNA-sequencing data to quantify mtDNA expression (mtRNA), and report analogously lower expression of mtRNA in tumors (relative to normal tissue) across a majority of cancer types. Several cancers exhibit a trio of mutually consistent evidence suggesting a drop in respiratory activity: depletion of mtDNA copy number, decreases in mtRNA levels, and decreases in expression of nuDNA-encoded respiratory proteins. Intriguingly, a minority of cancer types exhibit a drop in mtDNA expression but an increase in nuDNA expression of respiratory proteins, with unknown implications for respiratory activity. Our results indicate suppression of respiratory gene expression across many cancer types. © Reznik et al.
Journal Title:	eLife
Volume:	6
ISSN:	2050-084X
Publisher:	eLife Sciences Publications Ltd.
Date Published:	2017-01-18
Start Page:	e21592
Language:	English
DOI:	10.7554/eLife.21592
PROVIDER:	scopus
PMCID:	PMC5243113
PUBMED:	28099114
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010703363&doi=10.7554%2feLife.21592&partnerID=40&md5=ebaef9d13f47112126a7f68cc869f817
Notes:	Article -- Export Date: 2 March 2017 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/106685