Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst Journal Article

   

Authors:	Rayon, T.; Menchero, S.; Nieto, A.; Xenopoulos, P.; Crespo, M.; Cockburn, K.; Cañon, S.; Sasaki, H.; Hadjantonakis, A. K.; De La Pompa, J. L.; Rossant, J.; Manzanares, M.
Article Title:	Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst
Abstract:	The first lineage choice in mammalian embryogenesis is that between the trophectoderm, which gives rise to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper and the yolk sac. The establishment of these lineages is preceded by the inside-versus-outside positioning of cells in the early embryo and stochastic expression of key transcription factors, which is then resolved into lineage-restricted expression. The regulatory inputs that drive this restriction and how they relate to cell position are largely unknown. Here, we show an unsuspected role of Notch signaling in regulating trophectoderm-specific expression of Cdx2 in cooperation with TEAD4. Notch activity is restricted to outer cells and is able to influence positional allocation of blastomeres, mediating preferential localization to the trophectoderm. Our results show that multiple signaling inputs at preimplantation stages specify the first embryonic lineages. © 2014 Elsevier Inc.
Keywords:	immunohistochemistry; signal transduction; protein expression; unclassified drug; nonhuman; animal cell; mouse; mammalia; notch receptor; transcription factor; immunofluorescence; cell lineage; cellular distribution; preimplantation embryo; blastocyst; transcription factor cdx2; trophectoderm lineage; blastoma; priority journal; article; tead 4 protein
Journal Title:	Developmental Cell
Volume:	30
Issue:	4
ISSN:	1534-5807
Publisher:	Cell Press
Date Published:	2014-08-25
Start Page:	410
End Page:	422
Language:	English
DOI:	10.1016/j.devcel.2014.06.019
PROVIDER:	scopus
PMCID:	PMC4146744
PUBMED:	25127056
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84907597133&partnerID=40&md5=f6bd8be4ab2098d35fba814a219a4a67
Notes:	Export Date: 3 November 2014 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/64192