Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma Journal Article


Authors: Ardigo, M.; Buffon, R. B.; Scope, A.; Cota, C.; Buccini, P.; Berardesca, E.; Pellacani, G.; Marghoob, A. A.; Gill, M.
Article Title: Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma
Abstract: BACKGROUND Clear cell acanthoma (CCA) is a rare, benign neoplasm of unknown etiology, whose dermoscopic and histological features have been previously described. Usually, CCA can be diagnosed by clinical and dermoscopic examination. In some cases, diagnosis remains uncertain, and histological examination is needed. The aim of this paper was to describe the features of reflectance confocal microscopy (RCM) in diagnosing CCA, compare them with findings on dermoscopy and histology, and evaluate their possible usefulness in CCA evaluation. PATIENTS AND METHODS Five lesions diagnosed clinically as CCA were imaged using dermoscopy and RCM. All lesions were surgically excised to confirm the diagnosis and compare the morphological attributes under light microscopy with in vivo imaging. RESULTS RCM showed well-circumscribed lesions, often edged by a hyperkeratotic collarette with parakeratosis; inflammatory cells in the spinous layer; large keratinocytes; acanthosis with papillomatosis; epidermal disarray; and dilated capillaries forming glomeruloid shapes in the upper dermis. CONCLUSIONS In this small study, RCM was able to identify most of the established diagnostic histological features of CCA. RCM appears to be a useful tool for in vivo diagnosis of CCA and may help avoid unnecessary biopsies. Dr. Gill is a part-time research consultant for Lucid, Inc. © 2009 by the American Society for Dermatologic Surgery, Inc.
Keywords: adult; clinical article; controlled study; human tissue; aged; middle aged; cancer surgery; human cell; clinical feature; comparative study; reproducibility of results; dermoscopy; confocal microscopy; microscopy, confocal; skin neoplasms; epidermis; diagnosis, differential; in vivo study; acanthoma; acanthosis; biopsy; capillary; clear cell acanthoma; dermis; epiluminescence microscopy; histology; inflammatory cell; keratinocyte; morphology; papillomatosis; parakeratosis; histological techniques
Journal Title: Dermatologic Surgery
Volume: 35
Issue: 6
ISSN: 1076-0512
Publisher: Lippincott Williams & Wilkins  
Date Published: 2009-06-01
Start Page: 952
End Page: 959
Language: English
DOI: 10.1111/j.1524-4725.2009.01162.x
PUBMED: 19397663
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 30 November 2010" - "CODEN: DESUF" - "Source: Scopus"
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Alon Scope
    125 Scope
  2. Ashfaq A Marghoob
    537 Marghoob
  3. Melissa Gill
    23 Gill
Related MSK Work