Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna Journal Article


Authors: Cinotti, E.; Labeille, B.; Debarbieux, S.; Carrera, C.; Lacarrubba, F.; Witkowski, A. M.; Moscarella, E.; Arzberger, E.; Kittler, H.; Bahadoran, P.; Gonzalez, S.; Guitera, P.; Agozzino, M.; Farnetani, F.; Hofmann-Wellenhof, R.; Ardigò, M.; Rubegni, P.; Tognetti, L.; Łudzik, J.; Zalaudek, I.; Argenziano, G.; Longo, C.; Ribero, S.; Malvehy, J.; Pellacani, G.; Cambazard, F.; Perrot, J. L.
Article Title: Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna
Abstract: Background: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. Objective: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. Methods: A total of 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination was compared. Interinvestigator variability and confidence level in the diagnosis were also evaluated. Results: Overall diagnostic accuracy of the two imaging techniques was good (area under the curve of the sROC function: 0.89). RCM was more sensitive (80%, vs. 61%) and less specific (81% vs. 92%) than dermoscopy for LM/LMM. In particular, RCM showed a higher sensitivity for hypomelanotic and recurrent LM/LMM. RCM had a higher interinvestigator agreement and a higher confidence level in the diagnosis than dermoscopy. Conclusion: Reflectance confocal microscopy and dermoscopy are both useful techniques for the diagnosis of facial lesions and in particular LM/LMM. RCM is particularly suitable for the identification of hypomelanotic and recurrent LM/LMM. © 2018 European Academy of Dermatology and Venereology
Journal Title: Journal of the European Academy of Dermatology and Venereology
Volume: 32
Issue: 8
ISSN: 0926-9959
Publisher: Wiley Blackwell  
Date Published: 2018-08-01
Start Page: 1284
End Page: 1291
Language: English
DOI: 10.1111/jdv.14791
PROVIDER: scopus
PUBMED: 29341263
DOI/URL:
Notes: Article -- Export Date: 1 August 2018 -- Source: Scopus
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  1. Salvador Gonzalez Rodriguez
    203 Rodriguez