Reflectance confocal microscopy of pigmented basal cell carcinoma Journal Article
| Authors: | Chan Agero, A. L.; Busam, K. J.; Benvenuto-Andrade, C.; Scope, A.; Gill, M.; Marghoob, A. A.; Gonzalez, S.; Halpern, A. C. |
| Article Title: | Reflectance confocal microscopy of pigmented basal cell carcinoma |
| Abstract: | Background: Reflectance confocal microscopy (RCM) is a high-resolution imaging tool for in vivo noninvasive evaluation of skin lesions. Objective: We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC). Methods: Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis. Results: RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy. These tumor nests were associated with bright dendritic structures, identified histologically as either melanocytes or Langerhans cells, together with numerous bright oval to stellate-shaped structures with indistinct borders representing melanophages, and with highly refractile granules of melanin. Limitations: The pigmented BCCs imaged in this study were predominantly nodular; a different set or additional criteria may be necessary for detection of infiltrative and metatypical BCCs. Conclusion: RCM may permit in vivo diagnosis of pigmented BCC. © 2006 by the American Academy of Dermatology, Inc. |
| Keywords: | adult; clinical article; human tissue; aged; aged, 80 and over; middle aged; excision; human cell; histopathology; cell structure; melanoma; melanin; basal cell carcinoma; confocal microscopy; skin defect; microscopy, confocal; skin neoplasms; dendritic cell; melanocyte; diagnosis, differential; differential diagnosis; diagnostic imaging; epiluminescence microscopy; stellate cell; cell aggregation; carcinoma, basal cell; pigment disorder; langerhans cell; brightness |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 54 |
| Issue: | 4 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2006-04-01 |
| Start Page: | 638 |
| End Page: | 643 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2005.11.1096 |
| PUBMED: | 16546585 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 46" - "Export Date: 4 June 2012" - "CODEN: JAADD" - "Source: Scopus" |
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