Modeling adult gliomas using RCAS/t-va technology Journal Article
| Authors: | Hambardzumyan, D.; Amankulor, N. M.; Helmy, K. Y.; Becher, O. J.; Holland, E. C. |
| Article Title: | Modeling adult gliomas using RCAS/t-va technology |
| Abstract: | Malignant gliomas remain the most devastating childhood and adult tumors of the central nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they differ in location, behavior, and molecular characteristics. This implies that the molecular pathways and pathophysiology of malignant gliomagenesis in these two populations are distinct. Such differences between adult and pediatric gliomas may predict different therapeutic responses. Therefore, accurate genetically engineered models of adult and pediatric gliomas may help understand the biology of these tumors and evaluate therapeutic agents in preclinical studies. It has been proposed that gliomas arise from the subventricular zone in mice during development. Here, we demonstrate that, in adult mice, gliomas may arise not only when injected in the subventricular zone but also when injected in the cortex and cerebellum. Our work demonstrates a versatile and highly reproducible adult mouse model of glioma, which can be easily incorporated into preclinical studies. Copyright © 2009 Neoplasia Press, Inc. All rights reserved. |
| Keywords: | immunohistochemistry; platelet derived growth factor; cancer localization; nonhuman; pathophysiology; cancer patient; nuclear magnetic resonance imaging; glioma; animal cell; mouse; animal tissue; protein targeting; animal experiment; animal model; brain cortex; histology; central nervous system; carcinogenesis; transgenic mouse; genetic transfection; genetic engineering; cell culture; oncogene k ras; k ras protein; morphological trait; bioluminescence; cerebellum cortex; genetic engineering and gene technology; model |
| Journal Title: | Translational Oncology |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1936-5233 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 89 |
| End Page: | 95 |
| Language: | English |
| DOI: | 10.1593/tlo.09100 |
| PROVIDER: | scopus |
| PMCID: | PMC2670576 |
| PUBMED: | 19412424 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 30 November 2010" - "Source: Scopus" |
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