A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis Journal Article

  

Authors:	Bennett, J.; Levine, A. B.; Nobre, L.; Negm, L.; Chung, J.; Fang, K.; Johnson, M.; Komosa, M.; Krumholtz, S.; Nunes, N. M.; Rana, M.; Ryall, S.; Sheth, J.; Siddaway, R.; Bale, T. A.; Bouffet, E.; Cusimano, M. D.; Das, S.; Detsky, J.; Dirks, P.; Karajannis, M. A.; Kongkham, P.; Giantini-Larsen, A.; Li, B. K.; Lim-Fat, M. J.; Lin, A. L.; Mason, W. P.; Miller, A.; Perry, J. R.; Sahgal, A.; Sait, S. F.; Tsang, D. S.; Zadeh, G.; Laperriere, N.; Nguyen, L.; Gao, A.; Keith, J.; Munoz, D. G.; Tabori, U.; Hawkins, C.
Article Title:	A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis
Abstract:	Gliomas are a major cause of cancer-related deaths in adolescents and young adults (AYAs; ages 15–39 years). Different molecular alterations drive gliomas in children and adults, leading to distinct biology and clinical consequences, but the implications of pediatric- versus adult-type alterations in AYAs are unknown. Our population-based analysis of 1,456 clinically and molecularly characterized gliomas in patients aged 0–39 years addresses this gap. Pediatric-type alterations were found in 31% of AYA gliomas and conferred superior outcomes compared to adult-type alterations. AYA low-grade gliomas with specific RAS–MAPK alterations exhibited senescence, tended to arise in different locations and were associated with superior outcomes compared to gliomas in children, suggesting different cellular origins. Hemispheric IDH-mutant, BRAF p.V600E and FGFR-altered gliomas were associated with the risk of malignant transformation, having worse outcomes with increased age. These insights into gliomagenesis may provide a rationale for earlier intervention for certain tumors to disrupt the typical behavior, leading to improved outcomes. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.
Journal Title:	Nature Cancer
Volume:	6
Issue:	6
ISSN:	2662-1347
Publisher:	Nature Research
Publication status:	Published
Date Published:	2025-06-01
Start Page:	1102
End Page:	1119
Language:	English
DOI:	10.1038/s43018-025-00962-x
PROVIDER:	scopus
PUBMED:	40335748
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004690509&doi=10.1038%2fs43018-025-00962-x&partnerID=40&md5=15186c3dc77defe414dbbca544a53d29
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/228263