Histone-mutant glioma: Molecular mechanisms, preclinical models, and implications for therapy Review
| Authors: | Graham, M. S.; Mellinghoff, I. K. |
| Review Title: | Histone-mutant glioma: Molecular mechanisms, preclinical models, and implications for therapy |
| Abstract: | Pediatric high-grade glioma (pHGG) is the leading cause of cancer death in children. Despite histologic similarities, it has recently become apparent that this disease is molecularly distinct from its adult counterpart. Specific hallmark oncogenic histone mutations within pediatric malignant gliomas divide these tumors into subgroups with different neuroanatomic and chronologic predilections. In this review, we will summarize the characteristic molecular alterations of pediatric high-grade gliomas, with a focus on how preclinical models of these alterations have furthered our understanding of their oncogenicity as well as their potential impact on developing targeted therapies for this devastating disease. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
| Keywords: | pediatric high-grade glioma; diffuse midline glioma; h3k27m; oncohistone |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 21 |
| Issue: | 19 |
| ISSN: | 1422-0067 |
| Publisher: | MDPI |
| Date Published: | 2020-10-01 |
| Start Page: | 7193 |
| Language: | English |
| DOI: | 10.3390/ijms21197193 |
| PUBMED: | 33003625 |
| PROVIDER: | scopus |
| PMCID: | PMC7582376 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 November 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
269Mellinghoff -
22Graham
Related MSK Work