Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: A case series with molecular genetic analysis and review of the literature Journal Article
| Authors: | Cull, E. H.; Watts, J. M.; Tallman, M. S.; Kopp, P.; Frattini, M.; Rapaport, F.; Rampal, R.; Levine, R.; Altman, J. K. |
| Article Title: | Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: A case series with molecular genetic analysis and review of the literature |
| Abstract: | Central diabetes insipidus (DI) is a rare finding in patients with acute myeloid leukemia (AML), usually occurring in patients with chromosome 3 or 7 abnormalities. We describe four patients with AML and concurrent DI and a fifth patient with AML and panhypopituitarism. Four of five patients had monosomy 7. Three patients had chromosome 3q21q26/EVI-1 gene rearrangements. The molecular genotype of patients with AML and DI is not known. Therefore, we performed gene sequencing of 30 genes commonly mutated in AML in three patients with available leukemia cell DNA. One patient had no identifiable mutations, and two had RUNX1 F158S mutations. |
| Keywords: | myelodysplastic syndrome; abnormalities; acute myeloid leukemia; acute myeloblastic-leukemia; diabetes insipidus; chromosome-3; panhypopituitarism; monosomy-7 |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 55 |
| Issue: | 9 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2014-09-01 |
| Start Page: | 2125 |
| End Page: | 2129 |
| Language: | English |
| ACCESSION: | WOS:000340460200025 |
| DOI: | 10.3109/10428194.2013.869327 |
| PROVIDER: | wos |
| PUBMED: | 24286261 |
| Notes: | Article -- Source: Wos |
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