Small fiber abnormalities in skin biopsies of patients with benign fasciculations Journal Article
| Authors: | Tzatha, E.; Chin, R. L. |
| Article Title: | Small fiber abnormalities in skin biopsies of patients with benign fasciculations |
| Abstract: | Objective: To determine whether patients with benign fasciculations have evidence for axonal loss in skin biopsies. Methods: Epidermal sensory and sweat gland nerve fiber densities were quantified in skin biopsies of 11 patients with benign fasciculations and no other known cause for neuropathy. Results: Nine of the 11 patients (82%) had significantly reduced epidermal or sweat gland nerve fiber densities at the calf or thigh, in comparison with control values. Conclusions: The presence of reduced epidermal and sweat gland nerve fiber density indicates the presence of axonal loss in patients with benign fasciculations. Copyright © 2014 Lippincott Williams & Wilkins. |
| Keywords: | adult; clinical article; controlled study; human tissue; middle aged; skin biopsy; neuropathy; retrospective study; punch biopsy; nerve fiber; electromyography; cell density; arm; sweat gland; nerve conduction; fasciculation; motor unit; human; male; female; priority journal; article; axonal loss; benign fasciculations; epidermal nerve fiber density; small fiber neuropathy; sweat gland nerve fiber density |
| Journal Title: | Journal of Clinical Neuromuscular Disease |
| Volume: | 16 |
| Issue: | 1 |
| ISSN: | 1522-0443 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2014-09-01 |
| Start Page: | 12 |
| End Page: | 14 |
| Language: | English |
| DOI: | 10.1097/cnd.0000000000000047 |
| PROVIDER: | scopus |
| PUBMED: | 25137510 |
| DOI/URL: | |
| Notes: | Export Date: 1 October 2014 -- Source: Scopus |
