Quantitative collagen analysis for the detection of basal cell carcinoma with ex vivo multiphoton microscopy Conference Paper

  


Authors: Sendín-Martín, M.; Posner, J.; Harris, U.; Rajadhyaksha, M.; Kose, K.; Jain, M.
Editors: Choi, B.; Zeng, H.
Title: Quantitative collagen analysis for the detection of basal cell carcinoma with ex vivo multiphoton microscopy
Conference Title: Photonics in Dermatology and Plastic Surgery 2021
Abstract: Basal cell carcinoma (BCC) is the most common skin cancer worldwide. In the diagnosis process million benign biopsies are performed annually, increasing morbidity and healthcare costs. Noninvasive in vivo technologies such as multiphoton microscopy (MPM) can reduce biopsies. We explored the potential of MPM to differentiate collagen changes associated with BCC and surrounding normal skin structures using quantitative analysis (Fast Fourier transformation and Integrated optical density using ImageJ software, and its CurveAlign and CT-FIRE fiber analysis plugins) on second harmonic generation images. Our results showed that collagen distribution is more aligned surrounding BCCs when compared to the skin normal structures, showing the feasibility of detecting BCC in a quantitative way. Our initial results are limited to a small number of samples therefore, large-scale studies are needed to validate these collagen analysis methods. © 2021 SPIE.
Keywords: basal cell carcinoma; biopsy; computerized tomography; quantitative analysis; collagen; surgery; crystal structure; health care costs; multiphoton microscopy; dermatology; diseases; multiphoton processes; normal structure; second harmonic generation; nonlinear optics; analysis method; ct-fire; curvealign; fast fourier transformation; fast fourier transformations; large-scale studies; number of samples
Journal Title Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume: 11618
Conference Dates: 2021 Mar 6-11
Conference Location: Virtual
ISBN: 1605-7422
Publisher: SPIE  
Date Published: 2021-01-01
Start Page: 116180W
Language: English
DOI: 10.1117/12.2578776
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107473778&doi=10.1117%2f12.2578776&partnerID=40&md5=42fa27774897cfde29772f676d451644
Notes: Conference Paper -- Export Date: 1 July 2021 -- Source: Scopus
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MSK Authors
  1. Milind Rajadhyaksha
    222 Rajadhyaksha
  2. Kivanc Kose
    81 Kose
  3. Manu Jain
    76 Jain
  4. Ucalene Geneisha Harris
    29 Harris
  5. Jasmine Renee Posner
    3 Posner
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