Small-fiber neuropathy associated with capecitabine (Xeloda)-induced hand-foot syndrome: A case report Journal Article

  


Authors: Stubblefield, M. D.; Custodio, C. M.; Kaufmann, P.; Dickler, M. N.
Article Title: Small-fiber neuropathy associated with capecitabine (Xeloda)-induced hand-foot syndrome: A case report
Abstract: Hand-foot syndrome commonly results from treatment with capecitabine and is associated with pain, dysesthesias, paresthesias, and temperature intolerance. The cause of these symptoms in hand-foot syndrome has not been determined. We present the clinical, electrophysiologic, and biopsy data from a patient with capecitabine-induced hand-foot syndrome as supporting evidence implicating small-fiber neuropathy as the cause of these neuropathic symptoms. A patient with stage 4 breast cancer who develops capecitabine-induced hand-foot syndrome is referred for clinical and electrophysiologic testing. Intraepidermal nerve fiber density is assessed. Clinical evaluation demonstrates markedly decreased pain and temperature sensation with preserved strength, proprioception, and light touch. Standard electrodiagnostic testing is normal. The assessment of epidermal nerve fiber density demonstrates marked small-fiber loss both proximally and distally. In conclusion, small-fiber neuropathy is a likely cause of the neuropathic symptoms encountered in capecitabine-induced hand-foot syndrome. Similar clinical, electrophysiologic, and pathologic assessments are needed to confirm this finding in larger populations. © 2006 Lippincott Williams & Wilkins, Inc.
Keywords: adult; human tissue; case report; capecitabine; chemotherapy; breast cancer; skin biopsy; neuropathy; pathological anatomy; clinical study; celecoxib; nerve fiber; proprioception; electromyography; hand foot syndrome; neuropathic pain; electrophysiology; gabapentin; hand-foot syndrome; small-fiber neuropathy
Journal Title: Journal of Clinical Neuromuscular Disease
Volume: 7
Issue: 3
ISSN: 1522-0443
Publisher: Lippincott Williams & Wilkins  
Date Published: 2006-03-01
Start Page: 128
End Page: 132
Language: English
DOI: 10.1097/01.cnd.0000211401.19995.a2
PROVIDER: scopus
PUBMED: 19078798
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33749426611&partnerID=40&md5=464a4716fae40ad745db64c7ac486254
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 4 June 2012" - "CODEN: JCNDC" - "Source: Scopus"
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MSK Authors
  1. Maura N Dickler
    262 Dickler
  2. Christian M Custodio
    24 Custodio
  3. Michael Stubblefield
    52 Stubblefield
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