Two t lymphocyte populations as effector cells for igg dependent cytotoxicity Journal Article


Authors: Chiao, J. W.; Gee, T. S.; Good, R. A.
Article Title: Two t lymphocyte populations as effector cells for igg dependent cytotoxicity
Abstract: The characteristics and proportions of human lymphocyte populations capable of lysing IgG coated target cells were studied. Monolayers of target erythrocytes coated with rabbit IgG were employed to detect and isolate the lytic effector lymphocytes. Normal peripheral blood effector lymphocytes were shown to express IgG receptors, and a total of four cell types possessing different surface markers were identified. An average of 68% (range 51-80% of the effector lymphocytes had T lymphocyte antigen and were capable of SRBC rosette formation, and 32% of the lymphocytes lacked T lymphocyte markers. Two populations of these T lymphocytes were identified: one possesses SRBC and IgG receptors, and the other possesses SRBC, IgG and complement receptors. The proportion of the former was estimated as 53.2% and the latter as 14.8% of the total effector cell population. Two other cell types were distinguished among the non-T lymphocytes. One type of lymphocytes bear IgG receptors (21.6% and the other has both IgG and complement receptors (10.4% The cytolytic capacity of the two T lymphocyte subpopulations is suggested to be an important reaction of the immune reactive T lymphocytes during the immune response. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Journal Title: Immunological Investigations
Volume: 8
Issue: 2
ISSN: 0882-0139
Publisher: Informa Healthcare  
Date Published: 1979-01-01
Start Page: 213
End Page: 224
Language: English
DOI: 10.3109/08820137909048685
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 1 October 2014 -- Source: Scopus
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