Does the ribosome translate cancer? Journal Article
| Authors: | Ruggero, D.; Pandolfi, P. P. |
| Article Title: | Does the ribosome translate cancer? |
| Abstract: | Ribosome biogenesis and translation control are essential cellular processes that are governed at numerous levels. Several tumour suppressors and proto-oncogenes have been found either to affect the formation of the mature ribosome or to regulate the activity of proteins known as translation factors. Disruption in one or more of the steps that control protein biosynthesis has been associated with alterations in the cell cycle and regulation of cell growth. Therefore, certain tumour suppressors and proto-oncogenes might regulate malignant progression by altering the protein synthesis machinery. Although many studies have correlated deregulation of protein biosynthesis with cancer, it remains to be established whether this translates directly into an increase in cancer susceptibility, and under what circumstances. |
| Keywords: | oncoprotein; genetics; proto-oncogene proteins; review; neoplasm; neoplasms; cell cycle protein; metabolism; cell cycle proteins; gene; cell cycle; cancer susceptibility; proto oncogene; biological model; models, biological; cell growth; phosphatase; protein p53; physiology; cell transformation, neoplastic; tumor suppressor gene; biosynthesis; protein synthesis; cell transformation; myc protein; tumor suppressor proteins; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pten phosphohydrolase; protein biosynthesis; tumor suppressor protein p53; forecasting; cell size; familial cancer; ribosome rna; rna, ribosomal; tumor suppressor protein; proto-oncogene proteins c-myc; retinoblastoma protein; phosphoric monoester hydrolases; genes, tumor suppressor; genes, cdc; ribosomal proteins; ribosome protein; ribosomes; nucleolus; ribosome; proto-oncogenes; neoplastic syndromes, hereditary; cell nucleolus; priority journal |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-03-01 |
| Start Page: | 179 |
| End Page: | 192 |
| Language: | English |
| DOI: | 10.1038/nrc1015 |
| PUBMED: | 12612653 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
