Initiation of mRNA translation in oncogenesis: The role of eIF4E Journal Article

Authors: Montanaro, L.; Pandolfi, P. P.
Article Title: Initiation of mRNA translation in oncogenesis: The role of eIF4E
Abstract: The eukaryotic initiation factor 4E (eIF4E) is a key regulator of protein translation whose function is activated by the Akt and Ras proto-oncogenic signal transduction pathways. eIF4E enhances the translation of mRNAs encoding several genes involved in tumorigenesis and acts as a proto-oncogene, in vitro, when overexpressed in immortalized cells. Importantly, eIF4E is frequently found overexpressed in human cancers of multiple histological origins. However, in vivo evidence of the eIF4E neoplastic potential was lacking until now. Here we discuss recent findings that demonstrate eIF4E's oncogenic role in vivo through direct genetic approaches in the mouse, and identify novel oncogenic functions for this initiation factor in cooperative tumorigenesis and response to therapy. ©2004 Landes Bioscience.
Keywords: signal transduction; mitogen activated protein kinase; protein kinase b; protein phosphorylation; unclassified drug; raf protein; nonhuman; binding affinity; animals; mice; gene targeting; gene overexpression; proto oncogene; apoptosis; protein binding; drug resistance, neoplasm; carcinogenesis; mice, transgenic; cell transformation, neoplastic; protein kinase inhibitors; gene expression regulation, neoplastic; protein synthesis; mammalian target of rapamycin; lymphoma; initiation factor 4e; rna translation; protein biosynthesis; short survey; binding protein; gene control; models, genetic; ras protein; upregulation; senescence; antibiotics, antineoplastic; c-myc; oncogene c myc; rapamycin; mitogen activated protein kinase kinase; sirolimus; eukaryotic initiation factor-4e; ribosome; proto-oncogenes; eif4e; phosphatidylinositol kinase; cancer; humans; human; mrna translation; phosphatidylinositol kinase 3
Journal Title: Cell Cycle
Volume: 3
Issue: 11
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2004-11-01
Start Page: 1387
End Page: 1389
Language: English
PUBMED: 15492504
PROVIDER: scopus
DOI: 10.4161/cc.3.11.1251
Notes: Cited By (since 1996):16 -- Export Date: 16 June 2014 -- Source: Scopus
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