MNK, EIF4E and targeting translation for therapy Journal Article

Authors: Silva, R. L. A.; Wendel, H. G.
Article Title: MNK, EIF4E and targeting translation for therapy
Abstract: Deregulation of protein translation is a common event in cancer and occurs frequently as a result of mutational activation of the AKT signaling pathway. We had previously reported the in vivo oncogenic activity of the translation initiation factor eIF4E, which acts downstream AKT and mTOR1. We now identified an absolute requirement for Ser209 phosphorylation by the MNK1/2 kinases for eIF4E's oncogenic action.2 MNK1/2 kinases are dispensable for normal development in mammals.3 This potential difference between normal and cancer cells may provide a therapeutic avenue for targeting translational requirements in cancer. ©2008 Landes Bioscience.
Keywords: signal transduction; protein kinase b; protein phosphorylation; unclassified drug; mutation; nonhuman; neoplasm; neoplasms; mammalia; animals; mice; serine; protein targeting; in vivo study; phosphorylation; cancer therapy; carcinogenesis; cancer genetics; protein-serine-threonine kinases; cancer cell; initiation factor 4e; rna translation; protein biosynthesis; translation; short survey; development; mouse models; mammalian target of rapamycin inhibitor; protein kinase; therapy; eukaryotic initiation factor-4e; deregulation; eif4e; mnk1 kinase; mnk2 kinase
Journal Title: Cell Cycle
Volume: 7
Issue: 5
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2008-03-01
Start Page: 553
End Page: 555
Language: English
PUBMED: 18256539
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Ricardo Luis Alves Silva
    3 Silva
  2. Hans Guido Wendel
    80 Wendel