The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis Journal Article


Authors: Ruggero, D.; Montanaro, L.; Ma, L.; Xu, W.; Londei, P.; Cordon-Cardo, C.; Pandolfi, P. P.
Article Title: The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Abstract: The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (el F-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
Keywords: protein kinase b; nonhuman; cell proliferation; mouse; mammalia; animals; mice; animal tissue; apoptosis; gene expression; cell growth; protein kinases; animal model; phosphatidylinositol 3 kinase; histology; carcinogenesis; animalia; mice, transgenic; oncogene; b cell lymphoma; lymphoma, b-cell; genes, myc; lymphoma; initiation factor 4e; oncogene c myc; eukaryotic initiation factor-4e; target of rapamycin kinase; cocarcinogenesis; priority journal; article
Journal Title: Nature Medicine
Volume: 10
Issue: 5
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2004-01-01
Start Page: 484
End Page: 486
Language: English
DOI: 10.1038/nm1042
PROVIDER: scopus
PUBMED: 15098029
DOI/URL:
Notes: Nat. Med. -- Cited By (since 1996):308 -- Export Date: 16 June 2014 -- CODEN: NAMEF -- Source: Scopus
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MSK Authors
  1. Davide Ruggero
    13 Ruggero
  2. Li Ma
    6 Ma
  3. Wei   Xu
    2 Xu