The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis Journal Article

  

Authors:	Ruggero, D.; Montanaro, L.; Ma, L.; Xu, W.; Londei, P.; Cordon-Cardo, C.; Pandolfi, P. P.
Article Title:	The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Abstract:	The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (el F-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
Keywords:	protein kinase b; nonhuman; cell proliferation; mouse; mammalia; animals; mice; animal tissue; apoptosis; gene expression; cell growth; protein kinases; animal model; phosphatidylinositol 3 kinase; histology; carcinogenesis; animalia; mice, transgenic; oncogene; b cell lymphoma; lymphoma, b-cell; genes, myc; lymphoma; initiation factor 4e; oncogene c myc; eukaryotic initiation factor-4e; target of rapamycin kinase; cocarcinogenesis; priority journal; article
Journal Title:	Nature Medicine
Volume:	10
Issue:	5
ISSN:	1078-8956
Publisher:	Nature Publishing Group
Date Published:	2004-01-01
Start Page:	484
End Page:	486
Language:	English
DOI:	10.1038/nm1042
PROVIDER:	scopus
PUBMED:	15098029
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-2442648845&partnerID=40&md5=7c21b83dbfa3646584f9b25547a7186b
Notes:	Nat. Med. -- Cited By (since 1996):308 -- Export Date: 16 June 2014 -- CODEN: NAMEF -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/53272