Signaling control of mRNA translation in cancer pathogenesis Journal Article
| Authors: | Holland, E. C.; Sonenberg, N.; Pandolfi, P. P.; Thomas, G. |
| Article Title: | Signaling control of mRNA translation in cancer pathogenesis |
| Abstract: | The regulation of translation and the control of ribosome biogenesis are essential cellular processes whose impact on cell growth and proliferation is manifested at a number of specific levels. Disruption in one or more of the steps that control protein biosynthesis has been associated with alterations in the regulation of cell growth and cell cycle progression. Consistent with this, tumor suppressors and proto-oncogenes have been found to act on these functions and may therefore regulate malignant progression by affecting the protein synthetic machinery. Although many studies have correlated deregulation of protein biosynthesis with cancer, it remains to be established whether this process is necessary and/or sufficient for neoplastic transformation and metastasis. |
| Keywords: | signal transduction; s6 kinase; genetics; clinical trial; review; doxorubicin; drug efficacy; nonhuman; side effect; solid tumor; neoplasm; neoplasms; cell proliferation; animal; animals; cell cycle; proto oncogene; metastasis; cell growth; protein kinases; phosphorylation; phosphatidylinositol 3 kinase; physiology; carcinogenesis; temsirolimus; prostate cancer; tumor suppressor gene; correlation analysis; regulatory mechanism; messenger rna; protein synthesis; glioblastoma; mammalian target of rapamycin; 1-phosphatidylinositol 3-kinase; rna translation; protein biosynthesis; malignant neoplastic disease; pten; protein kinase; everolimus; rapamycin; mtor; biogenesis; ribosome; eif4e; rheb; ribosomal protein s6 kinases; cancer; humans; human; priority journal; mrna translation; tsc1/2 |
| Journal Title: | Oncogene |
| Volume: | 23 |
| Issue: | 18 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-04-19 |
| Start Page: | 3138 |
| End Page: | 3144 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1207590 |
| PROVIDER: | scopus |
| PUBMED: | 15094763 |
| DOI/URL: | |
| Notes: | Oncogene -- Cited By (since 1996):116 -- Export Date: 16 June 2014 -- CODEN: ONCNE -- Source: Scopus |
