Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus Journal Article
| Author: | Petrie, H. T. |
| Article Title: | Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus |
| Abstract: | Similar to all haematopoietic lineages, T cells must be replenished throughout life - a process that is the main function of the thymus. New progenitors are recruited to leave the bloodstream and enter the thymus, then to migrate in a defined pattern within the thymus during differentiation, and finally to return to the blood after maturation. Thereby, directional migration is intrinsically linked to all stages of T-cell differentiation. This review focuses on what is known and what is unknown about the signals that support this migration process in the mouse model of post-natal thymocyte differentiation. |
| Keywords: | review; nonhuman; t lymphocyte; t-lymphocytes; animal cell; mouse; animals; cell maturation; animal model; cell differentiation; cell lineage; stem cell; blood; thymus; thymus gland; cell migration; cell movement; lymphopoiesis; perinatal period; humans; priority journal |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 3 |
| Issue: | 11 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-11-01 |
| Start Page: | 859 |
| End Page: | 866 |
| Language: | English |
| PUBMED: | 14668802 |
| PROVIDER: | scopus |
| DOI: | 10.1038/nri1223 |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
