Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus Journal Article

  


Authors: Plotkin, J.; Prockop, S. E.; Lepique, A.; Petrie, H. T.
Article Title: Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus
Abstract: T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here we show that CXCL12/CXCR4 signaling is absolutely required for proper localization of early progenitors into the cortex and thus for successful steady state differentiation. All early progenitors in the thymus express CXCR4, and its ligand (CXCL12) is expressed only by stromal cells in the cortex, where early progenitors are found. Early progenitors migrate in response to CXCL12 in vitro, while thymus-specific deletion of CXCR4 in vivo results in failed cortical localization and developmental arrest. These findings indicate a crucial and nonredundant role for CXCR4 in facilitating localization of early lymphoid progenitors to tissue regions of the thymus, where lineage commitment and proliferation are controlled.
Keywords: signal transduction; nonhuman; protein localization; cd8 antigen; cell proliferation; animal cell; mouse; animals; mice; cell compartmentalization; vascular cell adhesion molecule 1; cell differentiation; mice, inbred c57bl; mice, transgenic; stem cell; thymus; thymus gland; hematopoietic cell; hematopoietic stem cells; cell migration; cell movement; t-lymphocyte subsets; cd4 antigen; animals, newborn; cytokeratin; keratins; stroma cell; stromal cells; cell interaction; t lymphocyte activation; receptors, chemokine; postnatal development; receptors, cxcr4; lymphoid cell; chemokine receptor cxcr4; alpha4 integrin; chemokines, cxc; clonal anergy; male; priority journal; article
Journal Title: Journal of Immunology
Volume: 171
Issue: 9
ISSN: 0022-1767
Publisher: The American Association of Immunologists, Inc  
Date Published: 2003-11-01
Start Page: 4521
End Page: 4527
Language: English
PUBMED: 14568925
PROVIDER: scopus
DOI: 10.4049/jimmunol.171.9.4521
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0142149043&partnerID=40&md5=2741d951441b41dabbeeac3c4eb4091e
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Ana P Lepique
    3 Lepique
  2. Susan E Prockop
    262 Prockop
  3. Howard T Petrie
    44 Petrie
  4. Jason Plotkin
    11 Plotkin
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