Functional assessment of αEβ7/E-cadherin interactions in the steady state postnatal thymus Journal Article
| Authors: | Prockop, S. E.; Petrie, H. T. |
| Article Title: | Functional assessment of αEβ7/E-cadherin interactions in the steady state postnatal thymus |
| Abstract: | T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here, we show that despite αEβ7 expression by a subset of the earliest intrathymic precursors (and E-cadherin expression by thymic stroma), interaction of these elements is not required for proper localization of early progenitors into the cortex, or for successful steady state differentiation. These findings indicate that despite in vitro data demonstrating αEβ7 mediated adhesion and proliferation of intrathymic T cell precursor populations, T lymphocyte development can proceed independently of αEβ7/ E-cadherin interactions. |
| Keywords: | functional assessment; genetics; nonhuman; flow cytometry; t lymphocyte; animal cell; mouse; animal; cytology; metabolism; mouse mutant; animals; mice; mice, knockout; cells, cultured; cell cycle; cell division; bone marrow; steady state; protein binding; protein interaction; uvomorulin; stem cell; chimera; rna; cell culture; thymus; thymus gland; oligonucleotide array sequence analysis; newborn; stem cells; dna microarray; hematopoietic stem cell; antigens, cd; animals, newborn; bone marrow transplantation; stroma cell; cadherin; cadherins; leukocyte antigen; integrin; transplantation chimera; integrins; t lymphocytes; histocompatibility; beta7 integrin; priority journal; article; lymphostromal; integrin alphaebeta7; thymus extract; thymus extracts |
| Journal Title: | Clinical and Developmental Immunology |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 1740-2522 |
| Publisher: | Hindawi Publishing Corporation |
| Date Published: | 2004-06-01 |
| Start Page: | 135 |
| End Page: | 141 |
| Language: | English |
| DOI: | 10.1080/10446670410001722212 |
| PROVIDER: | scopus |
| PMCID: | PMC2270712 |
| PUBMED: | 15330449 |
| DOI/URL: | |
| Notes: | Clin. Dev. Immunol. -- Cited By (since 1996):5 -- Export Date: 16 June 2014 -- CODEN: CDILB -- Source: Scopus |
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