Use of radiolabelled iododeoxyuridine as adjuvant treatment for experimental tumours of the liver Journal Article
| Authors: | Zager, J. S.; Delman, K. A.; Ebright, M. I.; Malhotra, S.; Larson, S.; Fong, Y. |
| Article Title: | Use of radiolabelled iododeoxyuridine as adjuvant treatment for experimental tumours of the liver |
| Abstract: | Background: The aim of the study was to determine whether hepatic regeneration stimulates growth of tumour residing within the liver, and whether a difference in the rate of DNA synthesis in liver and tumour may be used to target cancer using the radiolabelled thymidine analogue 5-iodo-2′- deoxyuridine (IUdR). Methods: Partial hepatectomy was performed on Buffalo rats bearing solitary nodules of syngeneic Morris hepatoma. Liver and tumour DNA synthesis was measured by incorporation of radioactive IUdR. [ 125I]IUdR was tested as an adjuvant therapy after hepatectomy in Buffalo rats bearing diffuse microscopic Morris hepatomas to simulate the clinical situation. Results: Liver regeneration enhanced liver and tumour DNA synthesis as measured by incorporation of radioactive IUdR. Liver DNA synthesis returned to baseline by 7 days, whereas tumour DNA synthesis remained above baseline level. Hepatectomy enhanced the growth of microscopic liver tumours. [125I]IUdR (250 μCi or 1 mCi/kg) administered 4 days after hepatectomy significantly reduced tumour growth without signs of systemic toxicity or liver dysfunction. Conclusion: The local environment of the regenerating liver stimulates tumour growth. The thymidine analogue [ 125I]IUdR may be used preferentially to target tumour DNA synthesis in the regenerating liver, and may prove useful as an adjuvant therapy for hepatic tumours after surgical resection. |
| Keywords: | controlled study; nonhuman; carcinoma, hepatocellular; cancer adjuvant therapy; animals; hepatocytes; animal model; tumor cells, cultured; liver; iodine 125; iodine 131; isotope labeling; liver tumor; rat; liver resection; hepatectomy; rats; experimental neoplasm; liver regeneration; tumor growth; portal vein; injections, intravenous; nucleic acid synthesis inhibitors; injections, intraperitoneal; liver neoplasms, experimental; idoxuridine; priority journal; article |
| Journal Title: | British Journal of Surgery |
| Volume: | 90 |
| Issue: | 10 |
| ISSN: | 0007-1323 |
| Publisher: | Oxford University Press |
| Date Published: | 2003-10-01 |
| Start Page: | 1225 |
| End Page: | 1231 |
| Language: | English |
| DOI: | 10.1002/bjs.4207 |
| PUBMED: | 14515291 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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