Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver Journal Article

  


Authors: Daghighian, F.; Humm, J. L.; Macapinlac, H. A.; Zhang, J.; Izzo, J.; Finn, R.; Kemeny, N.; Larson, S. M.
Article Title: Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver
Abstract: The radiotoxicity of 125I is highly sensitive to the site of decay relative to nuclear DNA. This paper describes a new approach, based upon pharmacokinetic clearance of radioactivity from the tumor, with which to quantify the fraction of [125I]IUdR incorporated within the DNA of tumor cells. Methods: Patients were injected with [125I]IUdR through the hepatic artery. Iodine-131 -IUdR was used as a tracer for imaging and quantitation. Both conventional and DNA-level dosimetry were performed. Results: We calculated that if 15% of the tumor cells were in S phase at the time of injection, there would be 250 decays of 125I in the DNA per tumor cell after an infusion of 5 mCi [125I]IUdR. According to in vitro data based on 5 × 108 cells per g tumor, 99% of these cells in S phase would be killed. Conclusion: The estimate of cell inactivation is strongly dependent on the number of cells per gram and the fraction of cells in S phase at the time of injection, which indicates that repeat injections would be necessary to achieve a therapeutic effect.
Keywords: liver neoplasms; radiation dose; metastasis; bone marrow; radiotherapy dosage; pathology; radiation exposure; colorectal neoplasms; liver; radioactive iodine; iodine radioisotopes; colorectal tumor; liver tumor; scintiscanning; intraarterial drug administration; radiometry; hepatic artery; injections, intra-arterial; idoxuridine; humans; human; article; iododeoxyuridine; auger electron; dna-level dosimetry
Journal Title: Journal of Nuclear Medicine
Volume: 37
Issue: 4 Suppl.
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 1996-04-01
Start Page: 29S
End Page: 32S
Language: English
PUBMED: 8676201
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030117608&partnerID=40&md5=180e38edfb74b70262faabf60145551f
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Ronald D Finn
    279 Finn
  2. Homer Macapinlac
    106 Macapinlac
  3. John Laurence Humm
    434 Humm
  4. Steven M Larson
    959 Larson
  5. Nancy Kemeny
    544 Kemeny
  6. Jiaju Zhang
    34 Zhang
  7. Farhad Daghighian
    37 Daghighian
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