Interferon gamma protects against hepatic tumor growth in rats by increasing Kupffer cell tumoricidal activity Journal Article
| Authors: | Karpoff, H. M.; Tung, C.; Ng, B.; Fong, Y. |
| Article Title: | Interferon gamma protects against hepatic tumor growth in rats by increasing Kupffer cell tumoricidal activity |
| Abstract: | An increasing number of hepatic resections are being performed as potentially curative surgery for malignant liver neoplasms. Hepatectomy and subsequent liver regeneration produce a local environment that enhances growth of microscopic residual tumor. To determine if pretreatment with murine interferon gamma (IFN-γ) can protect against such enhanced tumor growth, Buffalo rats were randomized to receive a 3-day treatment of IFN-γ (50,000 U/qD intraperitoneally) or saline. Groups then underwent intrasplenic injection of 106 Morris hepatoma cells, followed 1 hour later by sham (control) or partial hepatectomy (PH) of 70%. PH significantly enhanced tumor growth within the liver (control, 8 ± 3 nodules per liver; PH, 73 ± 12 nodules per liver; P < .001). This enhancement was attenuated by prior administration of IFN-γ IFN-γ/PH, 16 ± 3; P < .001 vs. PH). Growth factor release and liver regeneration were not affected significantly by pretreatment with IFN-γ. The effect of IFN-γ on tumor growth is associated with a significant enhancement of Kupffer cell (KC)-mediated tumoricidal activity (percentage of specific lysis, 55 ± 10% control, 78 ± 11% IFN-γ P < .01) but not lymphocyte-mediated tumoricidal activity. Because microscopic residual disease may be present after hepatectomies for cancer, IFN-γ may be a useful agent in retarding growth of residual tumors. |
| Keywords: | controlled study; splenectomy; liver cell carcinoma; nonhuman; animal cell; animal experiment; animal model; antineoplastic activity; cytokine; recombinant gamma interferon; rat; transforming growth factor beta1; kupffer cell; liver regeneration; tumor growth; partial hepatectomy; spleen cell; cell mediated cytotoxicity; basic fibroblast growth factor; intraperitoneal drug administration; male; priority journal; article |
| Journal Title: | Hepatology |
| Volume: | 24 |
| Issue: | 2 |
| ISSN: | 0270-9139 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1996-08-01 |
| Start Page: | 374 |
| End Page: | 379 |
| Language: | English |
| DOI: | 10.1002/hep.510240214 |
| PUBMED: | 8690407 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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