Pretreatment with IFN-γ decreases infectious complications after partial hepatectomy in the rat Journal Article
| Authors: | Blair, S. L.; Karpoff, H. M.; Hodyl, C.; Fong, Y. |
| Article Title: | Pretreatment with IFN-γ decreases infectious complications after partial hepatectomy in the rat |
| Abstract: | Infectious postoperative complications occur commonly after hepatectomy and may lead to a long hospital stay or death. The potential beneficial effects of interferon-γ (IFN-γ) in this setting were evaluated in a model of hepatectomy and sepsis in rodents. Incidence of bacterial translocation was measured in animals on days 1, 2, and 5 after partial hepatectomy. Macrophage function was quantified by in vitro tumoricidal activity and superoxide anion (O2/-) production. Survival after partial hepatectomy and cecal ligation and puncture (CLP) was recorded. After partial hepatectomy, bacterial translocation was decreased on days 1 and 2 in animals pretreated with IFN-γ (p < 0.05). Macrophages from animals treated with IFN-γ had higher in vitro tumoricidal activity and production of O2/- (p < 0.05). Hepatectomized animals pretreated with IFN-γ had an increased survival after CLP (p < 0.05). IFN-γ may be useful in decreasing the incidence of infectious complications after partial hepatectomy. |
| Keywords: | survival; controlled study; nonhuman; animal cell; animals; animal experiment; animal model; antineoplastic activity; drug evaluation, preclinical; bacteria (microorganisms); animalia; postoperative complication; postoperative complications; recombinant gamma interferon; rat; hepatectomy; rats; rodentia; macrophages; superoxide; superoxides; bacterial infection; bacterial infections; partial hepatectomy; cecum; rats, inbred f344; infectious complication; punctures; interferon type ii; intraperitoneal drug administration; constriction; macrophage function; bacterial translocation; male; priority journal; article |
| Journal Title: | Journal of Interferon and Cytokine Research |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1079-9907 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 1998-03-27 |
| Start Page: | 175 |
| End Page: | 180 |
| Language: | English |
| PUBMED: | 9555979 |
| PROVIDER: | scopus |
| DOI: | 10.1089/jir.1998.18.175 |
| DOI/URL: | |
| Notes: | Article -- Presented at the 49th Annual Cancer Symposium of the Society of Surgical Oncology which took place March 21-24, 1996 in Atlanta, Georgia -- Export Date: 12 December 2016 -- Source: Scopus |
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