A concise route to benzofused macrolactones via ynolides: Cycloproparadicicol Journal Article
| Authors: | Yang, Z. Q.; Danishefsky, S. J. |
| Article Title: | A concise route to benzofused macrolactones via ynolides: Cycloproparadicicol |
| Abstract: | A new facile synthesis has been developed for nanomolar Hsp90 inhibitor, cycloproparadicicol (2). Our approach relied on cobalt-complexation promoted RCM, in combination with tandem Diels-Alder/retro-Diels-Alder reactions to assemble the resorcycinylic macrolactone. Copyright © 2003 American Chemical Society. |
| Keywords: | unclassified drug; drug activity; antineoplastic agent; drug synthesis; cyclopropanes; cyclization; macrolide; technique; chemical reaction; ring closing metathesis; cycloproparadicicol; lactone derivative; cycloaddition; lactones; macrolides; resorcinols; article |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 125 |
| Issue: | 32 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2003-08-13 |
| Start Page: | 9602 |
| End Page: | 9603 |
| Language: | English |
| DOI: | 10.1021/ja036192q |
| PUBMED: | 12904022 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
