Fusion of cells by flipped SNAREs Journal Article
| Authors: | Hu, C.; Ahmed, M.; Melia, T. J.; Söllner, T. H.; Mayer, T.; Rothman, J. E. |
| Article Title: | Fusion of cells by flipped SNAREs |
| Abstract: | The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes. |
| Keywords: | protein expression; mutation; protein domain; proteins; animals; nerve tissue proteins; protein; protein binding; membrane proteins; protein interaction; transfection; cercopithecus aethiops; cos cells; endoplasmic reticulum; recombinant fusion proteins; genetic engineering; cell membrane; glycosylation; cell membranes; protein structure, tertiary; protein folding; antigens, surface; cell fusion; cell surface; membrane; membrane fusion; snare protein; syntaxin 1; r-snare proteins; synaptosomal-associated protein 25; priority journal; article; cell expression |
| Journal Title: | Science |
| Volume: | 300 |
| Issue: | 5626 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2003-06-13 |
| Start Page: | 1745 |
| End Page: | 1749 |
| Language: | English |
| DOI: | 10.1126/science.1084909 |
| PUBMED: | 12805548 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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