A SNARE required for retrograde transport to the endoplasmic reticulum Journal Article
| Authors: | Burri, L.; Varlamov, O.; Doege, C. A.; Hofmann, K.; Beilharz, T.; Rothman, J. E.; Söllner, T. H.; Lithgow, T. |
| Article Title: | A SNARE required for retrograde transport to the endoplasmic reticulum |
| Abstract: | SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-/ike tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin. |
| Keywords: | unclassified drug; sequence analysis; nonhuman; protein localization; complex formation; cell protein; membrane proteins; endoplasmic reticulum; amino acid sequence; molecular sequence data; sequence homology, amino acid; saccharomyces cerevisiae; eukaryota; protein transport; protein secretion; saccharomyces cerevisiae proteins; eukaryotic cell; secretion; genome, fungal; vesicular transport proteins; membrane fusion; snare protein; syntaxin; biological transport, active; snare proteins; priority journal; article; qc-snare proteins; slt1; tail-anchored protein; protein sec20; protein sec22; protein slt1 |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 100 |
| Issue: | 17 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2003-08-19 |
| Start Page: | 9873 |
| End Page: | 9877 |
| Language: | English |
| DOI: | 10.1073/pnas.1734000100 |
| PUBMED: | 12893879 |
| PROVIDER: | scopus |
| PMCID: | PMC187870 |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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